Regulation of limb bud initiation and limb-type morphology
نویسندگان
چکیده
منابع مشابه
Cyclosporine Effects on Chick Limb Bud Mesenchyme and DNA Content
Background: Cyclosporine A (CsA) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. Many transplant recipients must take this medicine for the rest of their lives. Females in reproductive age group on prolonged CsA therapy have legitimate concerns about drug effects on pregnancy. Objective: To explore Cs...
متن کاملRetinoic acid and chick limb bud development.
The chick limb bud is a powerful experimental system in which to study pattern formation in vertebrate embryos. Exogenously applied retinoic acid, a vitamin A derivative, can bring about changes in pattern and, on several grounds, is a good candidate for an endogenous morphogen. As such, the local concentration of retinoic acid might provide cells with information about their position in relati...
متن کاملcyclosporine effects on chick limb bud mesenchyme and dna content
background: cyclosporine a (csa) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. many transplant recipients must take this medicine for the rest of their lives. females in reproductive age group on prolonged csa therapy have legitimate concerns about drug effects on pregnancy. objective: to explore ...
متن کاملGrowth Based Morphogenesis of Vertebrate Limb Bud
Many genes and their regulatory relationships are involved in developmental phenomena. However, by chemical information alone, we cannot fully understand changing organ morphologies through tissue growth because deformation and growth of the organ are essentially mechanical processes. Here, we develop a mathematical model to describe the change of organ morphologies through cell proliferation. ...
متن کاملThe roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.
Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the intermediate mesoderm (IM) has been proposed to play a critical role in the initiation of limb bud ...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2011
ISSN: 1058-8388
DOI: 10.1002/dvdy.22582